Nuclear Magnetic Resonance (NMR)

NMR Comparability Studies for Biosimilars: Ichor has priority access to the NMR facilities and high field instrumentation necessary to collect your FDA required biosimilarity data. Ichor offers fast turnaround times to make your deadlines, in addition to personalized, attentive, and thoughtful project management and bolt-on consulting and data analysis services.

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Protein Services Biophysical assays NMR Services

Nuclear Magnetic

High-Throughput FBDD and Binding Studies: Our services include 1H and 19F binding assays (FAXS, STD-NMR, WaterLOGSY), in addition to various 2D correlation experiments such as 1H-1H (COSY, NOESY, ROESY), 1H-15N (SOFAST-HMQC) and 1H-13C (ALSOFAST-HMQC) correlation spectroscopy.

Multiple instruments are equipped with SampleJet robots, allowing for low volume and/or 96 well plate screening formats. Also offered are services for production of isotopically enriched recombinant proteins.

Popular FBDD and Biosimilar NMR Services

Ichor offers all the cutting edge NMR experiments for Fragment-Based Drug Discovery and Biosimilar Comparability.

FAXS

FBDD via 19F NMR–Fluorine chemical shift Anisotropy and eXchange for Screening experiments (FAXS).

STD-NMR

Fragment Screening via STD-NMR –May also be used for Ligand Mapping and KD determination.

WaterLOGSY

A sensitive ligand-observed NMR experiment for detection of interactions between a ligand and a protein; well-established screening technique for FBDD.

Distance Calculations

Using Mahalanobis Distance and PCE Analysis (1D & 2D) in the Comparison of Biosimilars.

2D Correlation Spectroscopy–Biosimilars

Application of 2D NMR “Fingerprint” Spectra to Compare Biosimilar mAb Therapeutics.

2D Correlation Spectroscopy–Binding Studies

Quantitate protein/ligand binding interactions via N-H Chemical Shift Perturbations (CSPs). Proteins <30 kDa are amenable to the technique.

Data Acquisition

Ichor offers various 1D and 2D NMR experiments from everything from small molecules to antibodies and other complex biologics:

Related Products & Services:

Isotopically Enriched Protein Production & Data Analysis Services

Enriched Protein Production

Add-On Services to Supply Your Entire Pipeline:

STD-Difference Spectra

Consulting & Data Analysis

For more complex, nuanced, or data intensive projects, NMR specialists are available for hourly consultation.

2D NMR Ligand Titration image

Production of Isotopically Enriched Recombinant Proteins

We offer recombinant protein production with heavy isotope incorporation (2H, 13C, & 15N). Please inquire about discounts for bundling in-house protein production services with our analytical offerings.

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Most NMR studies start within 2 weeks of receipt of materials.

We are your Biophysics Lab down the hall.

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