Ahmed N R, Kulkarni V, Pokhrel S, et al. (May 08, 2022) Comparing the Efficacy and Safety of Obeticholic Acid and Semaglutide in Patients With Non-Alcoholic Fatty Liver Disease: A Systematic Review. Cureus 14(5): e24829. doi:10.7759/cureus.24829

NAFLD is estimated to affect more than one-quarter of the global population while the prevalence of NASH is estimated to be at least 3 - 5%. With obesity and metabolic disorders expected to continue their global trend upward, NAFLD/NASH rates are also projected to climb, bringing with them increasing rates of hepatocellular carcinoma (HCC).

Reliable and translatable models for researching the drivers of NASH and gauging the effectiveness of new pharmaceutical compounds are becoming ever more critical.

Ob/Ob HFD Mouse Models

High-fat diet in a mouse model with a genetic background for obesity and related characteristics.

CCl4 Model of Liver Fibrosis

One of the first described murine models for NASH - a reliable and historic model with a chemical challenge.

STZ HFD Mouse Model

Combines a high-fat diet with a diabetes-like phenotype. Flexible study designs to suit many needs.

Friedman Model

A combination of two highly effective challenges - diet (high in fat, fructose, and cholesterol) and CCl4.

Flexible and Customizable Analytical Assays

Track research progress with real-time updates to study tasks and milestones. Collect robust and meaningful data.

We are your Biophysics Lab down the hall.